Martin KLEIN
Regular membership
Université de Sherbrooke
Département de Médecine, Faculté de Médecine et des Sciences de la Santé
3001, 12ème Avenue Nord
, Sherbrooke
(Québec)
J1H5N4
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Areas of research
- Asthme
- Communication intercellulaire
- Inflammation
- Epithélium
- Cellules régulatrices
University
Université de Sherbrooke
Primary axis of the AIRS Network
Omics and biological determinants of health
Secondary axis(s)
Care, prevention and health promotion
Research sectors
- Health
Research types
- Fundamental
- Translational
Diplomas
- Ph.D
Research work
Mes recherches se concentrent sur l'asthme et notamment les cellules T et B régulatrices, ainsi que sur les cellules épithéliales bronchiques. Ma programmation de recherche s'intéresse à 1) l'étude de la dysfonction des cellules T et B régulatrices au cours du développement de l'asthme, 2) de caractériser la communication entre les cell...
Bibliographic references and DOIs
Klein M, Gagnon PA, Salem M, Rouabhia M, Chakir J. MicroRNA-155-5p Differentially Regulates IL-13Rα1 and IL-13Rα2 Expression and Signaling Driving Abnormal Lung Epithelial Cell Phenotype in Severe Asthma. Am J Respir Cell Mol Biol. 2024 Nov;71(5):603-616. doi: 10.1165/rcmb.2024-0089OC. PMID: 39051933.
Klein M, Plante S, Boulay MÈ, Boulet LP, Chakir J. Discrepancy in the suppressive function of regulatory T cells in allergic asthmatic vs. allergic rhinitis subjects upon low-dose allergen challenges. Front Allergy. 2023 Dec 1;4:1296601. doi: 10.3389/falgy.2023.1296601. PMID: 38106504; PMCID: PMC10722309.
Klein M, Dijoux E, Cheminant MA, Intes L, Bouchaud G. GliSODin® prevents airway inflammation by inhibiting T-cell differentiation and activation in a mouse model of asthma. Front Allergy. 2023 Jun 6;4:1199355. doi: 10.3389/falgy.2023.1199355. PMID: 37346413; PMCID: PMC10279865.
Klein M, Misme-Aucouturier B, Cheminant MA, De Carvalho M, Wauters M, Tranquet O, Magnan A, Bouchaud G. Engineering a safe monoclonal anti-human IL-2 that is effective in a murine model of food allergy and asthma. Allergy. 2022 Mar;77(3):933-945. doi: 10.1111/all.15029. Epub 2021 Aug 7. PMID: 34324715.
Klein M, Colas L, Cheminant MA, Brosseau C, Sauzeau V, Magnan A, Bouchaud G. Der p 2.1 Peptide Abrogates House Dust Mites-Induced Asthma Features in Mice and Humanized Mice by Inhibiting DC-Mediated T Cell Polarization. Front Immunol. 2020 Nov 18;11:565431. doi: 10.3389/fimmu.2020.565431. PMID: 33312170; PMCID: PMC7708318.