Darcy Wagner
Regular membership
McGill University
Biomedical Engineering and Medicine
1001 Décarie Blvd., Block E
, Montreal
(Quebec)
H3J 1P1
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Areas of research
- pulmonary fibrosis
- lung regeneration
- alveolar type II cells
- human lung tissue models
University
McGill University
Primary axis of the AIRS Network
Omics and biological determinants of health
Secondary axis(s)
axe2
Research sectors
- Health
- Nature & Technology
Research types
- Fundamental
- Translational
Diplomas
- B.ing
- Ph.D
Research work
Our lab focuses on how the extracellular environment directs stem cell behavior for endogenous and exogenous lung tissue regeneration. We use a multidisciplinary approach using advances in materials science (polymer design and synthesis), manufacturing (e.g. 3D bioprinting), and endogenous and iPSC-derived lung stem cells to construct these new ...
ORCID NUMBER:
https://orcid.org/0000-0003-3794-1309
Bibliographic references and DOIs
Wagner, D.E., Alsafadi, H.N., Mitash, N. et al. Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models. Nat Commun 16, 7099 (2025). https://doi.org/10.1038/s41467-025-61795-x
Modeling IPF in iPSC-derived alveolar organoids Victoria Ptasinski, Susan J Monkley, Karolina Öst, Markus Tammia, Hani N Alsafadi, Catherine Overed-Sayer, Petra Hazon, Darcy E Wagner, Lynne A Murray Life Science Alliance May 2023, 6 (8) e202201853. https://doi.org/10.26508/lsa.202201853
Victoria A. Ptasinski, John Stegmayr, Maria G. Belvisi, Darcy E. Wagner, Lynne A. Murray, Targeting Alveolar Repair in Idiopathic Pulmonary Fibrosis, American Journal of Respiratory Cell and Molecular Biology, Volume 65, Issue 4, October 2021, Pages 347–365, https://doi.org/10.1165/rcmb.2020-0476TR
Optimizing miRNA transfection for screening in precision cut lung slices Joanna Nowakowska, Nika Gvazava, Wojciech Langwiński, Kamil Ziarniak, Iran Augusto N. da Silva, John Stegmayr, Darcy E. Wagner, and Aleksandra Szczepankiewicz American Journal of Physiology-Lung Cellular and Molecular Physiology 2024 327:5, L712-L723. https://doi.org/10.1152/ajplung.00138.2024
Alsafadi HN, Staab-Weijnitz CA, Lehmann M, Lindner M, Peschel B, Königshoff M, Wagner DE. An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices. Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L896-L902. doi: 10.1152/ajplung.00084.2017. Epub 2017 Mar 17. Erratum in: Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1;318(4):L844. doi: 10.1152/ajplung.zh5-7811-corr.2020