Andres Bruno Rojas Ruiz
3rd cycle student member
Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Université Laval.
Faculté de Médecine
2725 Chemin Ste-Foy, Québec, QC
, Quebec
(Québec)
G1V 4G5
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Areas of research
- Hypoxie chronique
- Maladies respiratoires
- Adaptation à la haute altitude
- Asthme
- Mécanique respiratoire
University
Université Laval
Primary axis of the AIRS Network
Environmental quality measurements
Secondary axis(s)
Environmental quality measurements
Research sectors
- Health
Research types
- Fundamental
Diplomas
- B.Sc
- M.Sc
Research work
My research examines the impact of hypoxia on lung function, with particular emphasis on respiratory mechanics in a murine model of allergic asthma. BALB/c mice are exposed to fixed periods of normobaric hypoxia to evaluate alterations in respiratory mechanics, allergic inflammation, and airway responsiveness. The primary objective is to determi...
My research examines the impact of hypoxia on lung function, with particular emphasis on respiratory mechanics in a murine model of allergic asthma. BALB/c mice are exposed to fixed periods of normobaric hypoxia to evaluate alterations in respiratory mechanics, allergic inflammation, and airway responsiveness. The primary objective is to determine whether controlled hypoxic exposure can provide therapeutic benefits by attenuating key features of asthma. Ultimately, this study aims to contribute to the development of novel strategies for the management of respiratory diseases.
NAME OF DIRECTOR:
Ynuk Bossé
ORCID NUMBER:
0000-0002-3780-4278
Bibliographic references and DOIs
Rojas-Ruiz, A., Boucher, M., Henry, C., Gélinas, L., Packwood, R., Graham, P., Soliz, J., & Bossé, Y. (2025). Methacholine hyperresponsiveness in mice with house dust mite-induced lung inflammation is not associated with excessive airway constriction ex vivo. Experimental Physiology, 1–13. https://doi.org/10.1113/EP092522
Boucher M., Henry C., Gélinas L., Packwood R., Rojas-Ruiz Andrés, Fereydoonzad L., Graham P. & Bossé, Y. High throughput screening of airway constriction in mouse lung slices. Scientific Reports 14, 20133 (2024). https://doi.org/10.1038/s41598-024-71170-3
Rojas-Ruiz, A., Boucher, M., Henry, C. et al. Lung Volumes in a Mouse Model of Pulmonary Allergic Inflammation. Lung 202, 637–647 (2024). https://doi.org/10.1007/s00408-024-00730-1
Rojas-Ruiz A., Boucher M., Gill R., Gélinas L., Tom F.Q., Fereydoonzad L., Graham P., Soliz J. & Bossé Y. Lung stiffness of C57BL/6 versus BALB/c mice. Scientific Reports 13, 17481 (2023). https://doi.org/10.1038/s41598-023-44797-x
Boucher M., Dufour-Mailhot A., Tremblay-Pitre S., Khadangi F., Rojas-Ruiz A, Henry C. & Bossé, Y. In mice of both sexes, repeated contractions of smooth muscle in vivo greatly enhance the response of peripheral airways to methacholine. Respiratory Physiology & Neurobiology. 304:103938 (2022) https://doi.org/10.1016/j.resp.2022.103938